Related Experiment Video

Updated: Jul 5, 2026

Microsurgical Skills of Establishing Permanent Jugular Vein Cannulation in Rats for Serial Blood Sampling of Orally Administered Drug
08:28

Microsurgical Skills of Establishing Permanent Jugular Vein Cannulation in Rats for Serial Blood Sampling of Orally Administered Drug

Published on: December 14, 2021

Pharmacokinetics and tissue distribution of anidulafungin in rats

Bharat Damle1, Martin Stogniew, James Dowell

  • 1Pfizer Inc., New York, New York 10017, USA. bharat.damle@pfizer.com

Antimicrobial Agents and Chemotherapy
|April 30, 2008
PubMed

Insights

Anidulafungin distributes rapidly into rat tissues, maintaining antifungal levels for over 72 hours. Key organs like the liver and lungs showed significantly higher drug exposure compared to plasma.

Area of Science:

  • Pharmacology
  • Mycology
  • Drug Metabolism and Distribution

Background:

  • Anidulafungin is an echinocandin antifungal agent.
  • Understanding tissue distribution is crucial for optimizing antifungal therapy.
  • Fungal infections require effective drug concentrations at infection sites.

Purpose of the Study:

  • To evaluate the pharmacokinetic profile and tissue distribution of anidulafungin in a rat model.
  • To determine the duration of effective anidulafungin concentrations in various tissues.

Main Methods:

  • Anidulafungin was administered to rats.
  • Tissue and plasma samples were collected at various time points.
  • Drug concentrations were quantified using validated analytical methods.

Main Results:

  • Anidulafungin exhibited rapid tissue distribution, reaching peak concentrations within 30 minutes.
  • Antifungal concentrations remained above the minimum inhibitory concentrations (MICs) for common fungal pathogens for over 72 hours.
  • Exposure in infection-susceptible tissues (liver, lung, spleen, kidney) was 9- to 12-fold higher than in plasma.

Conclusions:

  • Anidulafungin demonstrates favorable tissue penetration and prolonged retention in rats.
  • High drug exposure in key organs suggests potential efficacy against systemic fungal infections.
  • These findings support the clinical utility of anidulafungin in treating invasive fungal diseases.

More Related Videos

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii09:17

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Published on: January 2, 2017

An Optimized Protocol for Candida albicans Infection in Schmidtea mediterranea to Study Fungal Pathogenesis and Host Defense06:53

An Optimized Protocol for Candida albicans Infection in Schmidtea mediterranea to Study Fungal Pathogenesis and Host Defense

Published on: April 17, 2026

Related Concept Videos

Pharmacodynamic Models: Overview01:27

Pharmacodynamic Models: Overview

Pharmacodynamic (PD) responses describe the interaction between a drug and its biological target, culminating in a physiological effect. These responses can be classified into different types: continuous variables, such as blood glucose levels; categorical outcomes, like survival rates; and time-to-event metrics, such as disease progression. Understanding and modeling PD responses are critical for optimizing drug efficacy and safety.PD models describe the relationship between drug concentration...
Estimation of k and VD of Aminoglycosides01:20

Estimation of k and VD of Aminoglycosides

Aminoglycosides are a class of antibiotics used to treat various bacterial infections. Clinicians must determine the elimination rate constant (k) and volume of distribution (VD) to optimize therapeutic efficacy and minimize toxicity. The k value represents the rate at which the drug is removed from the body, and the VD reflects the degree to which the drug distributes into body tissues. Accurately estimating these parameters allows healthcare professionals to tailor drug dosing to individual...
Drug Distribution: Tissue Binding01:21

Drug Distribution: Tissue Binding

Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Measurement of Bioavailability: Pharmacokinetic Methods01:30

Measurement of Bioavailability: Pharmacokinetic Methods

Pharmacokinetics is a vital branch of pharmacology that examines how drugs are absorbed, distributed, metabolized, and excreted by the body. Two key methodologies in pharmacokinetics are plasma drug concentration studies and urinary drug excretion analyses, both of which provide critical insights into a drug's therapeutic efficacy and bioavailability.Plasma Drug Concentration-Time StudiesPlasma drug concentration-time studies involve analyzing blood samples at specific intervals to quantify...
Factors Affecting Drug Distribution: Organ Perfusion Rate01:15

Factors Affecting Drug Distribution: Organ Perfusion Rate

Drug distribution within the body is a complex process influenced by several factors, including perfusion rate, the rate at which the bloodstream transports drugs to tissue. This limitation becomes particularly significant when dealing with highly lipophilic drugs. In such cases, the rate at which the drug can move across membranes is crucial, and if the membrane is highly permeable to the drug, distribution becomes rate-limited by perfusion.
Perfusion rate-limited distribution relies on the...