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Related Experiment Video

Updated: Jul 5, 2026

Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation

Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation

Published on: October 25, 2024

Ovarian reserve.

Maria Elisabetta Coccia¹, Francesca Rizzello

¹Department of Gynaecology, Perinatology and Human Reproduction, University of Florence, 50100 Florence, Italy. cocciame@tin.it

Annals of the New York Academy of Sciences

|April 30, 2008

Summary

This summary is machine-generated.

Women delaying pregnancy face infertility due to decreased ovarian reserve. Combining multiple tests, not just one, can accurately predict fertility and guide ovarian stimulation for better in vitro fertilization outcomes.

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Area of Science:

Reproductive Endocrinology
Infertility Research
Assisted Reproductive Technologies

Background:

Social trends lead women to postpone childbirth, increasing infertility risks.
Aging oocytes and diminished ovarian reserve are primary causes of age-related infertility.
Accurate ovarian reserve screening is crucial for predicting pregnancy chances and optimizing fertility treatments.

Purpose of the Study:

To evaluate the effectiveness of various tests in assessing ovarian reserve.
To identify reliable predictors of pregnancy success and response to ovarian stimulation.
To determine if a combination of tests offers superior accuracy over single markers.

Main Methods:

Review of hormonal markers: follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, inhibin, anti-Müllerian hormone.
Assessment of ultrasound parameters: ovarian volume, antral follicle count.
Inclusion of dynamic tests (GnRH agonist, FSH, clomiphene citrate) and ovarian biopsy.

Main Results:

No single test accurately predicts ovarian reserve or treatment success.
Simultaneous evaluation of multiple tests shows promise.
Combined testing serves as a sensitive predictor of diminished ovarian reserve and stimulation response.

Conclusions:

A comprehensive approach combining various hormonal and ultrasound markers is necessary for accurate ovarian reserve assessment.
This multi-test strategy can guide personalized in vitro fertilization (IVF) treatment protocols.
Improved prediction of ovarian response can enhance IVF success rates for women with delayed childbearing.