Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endometriosis and tissue factor.

Graciela Krikun1, Frederick Schatz, Hugh Taylor

  • 1Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine. 333 Cedar St., P.O. Box 208063, New Haven, CT, 06520-8063, USA. graciela.krikun@yale.edu

Annals of the New York Academy of Sciences
|April 30, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: The 4th international expert forum on the public health and environmental impacts of cellular and wireless radiation exposure 2024.

Frontiers in public health·2026
Same author

The Jacobins of medicine: how ideological zeal imperils professional integrity.

The American journal of medicine·2025
Same author

Advancing physician-scientist career development in obstetrics and gynecology: 40 years of the American Association of Obstetricians and Gynecologists Foundation scholar program.

American journal of obstetrics and gynecology·2025
Same author

Two-year follow-up study (PRIMROSE 3) to assess bone mineral density in subjects with uterine fibroids completing the PRIMROSE 1 and PRIMROSE 2 linzagolix trials.

Human reproduction open·2025
Same author

Linzagolix with and without hormonal add-back therapy for symptomatic uterine fibroids: PRIMROSE 1 & 2 long-term extension and withdrawal study.

Fertility and sterility·2025
Same author

CD34<sup>+</sup>KLF4<sup>+</sup> Stromal Stem Cells Contribute to Endometrial Regeneration and Repair.

Cell reports·2025
Same journal

Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin-1 in B Cells.

Annals of the New York Academy of Sciences·2026
Same journal

Global Trends in Light Pollution and Their Relationship With Socioeconomic Factors.

Annals of the New York Academy of Sciences·2026
Same journal

Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.

Annals of the New York Academy of Sciences·2026
Same journal

LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.

Annals of the New York Academy of Sciences·2026
Same journal

Polyrhythm Perception and Production: A Scoping Review.

Annals of the New York Academy of Sciences·2026
Same journal

DARTS-CNN-BiLSTM: Intelligent Fault Diagnosis for Computer Numerical Control Machine Tool Feed System.

Annals of the New York Academy of Sciences·2026
See all related articles

Tissue factor (TF) is altered in endometriosis, promoting inflammation and potentially serving as a therapeutic target. Targeting TF may offer new treatment options for endometriosis patients.

Area of Science:

  • Reproductive biology
  • Hemostasis
  • Inflammation

Background:

  • Tissue factor (TF) initiates blood coagulation and is implicated in angiogenesis.
  • TF interacts with factor VIIa and protease-activated receptor-2 (PAR-2).
  • Endometriosis is characterized by inflammation in endometrial tissues.

Purpose of the Study:

  • To review studies on TF expression in endometriosis.
  • To investigate the role of TF in the inflammatory processes of endometriosis.
  • To evaluate TF as a potential therapeutic target for endometriosis.

Main Methods:

  • Review of laboratory studies on TF expression in eutopic and ectopic endometrium.
  • Analysis of TF signaling pathways involving PAR-2.
  • Assessment of inflammatory markers and macrophage recruitment in relation to TF.

Related Experiment Videos

Main Results:

  • TF expression patterns and levels are altered in endometrial cells from women with endometriosis.
  • High TF expression in diseased endometrium correlates with inflammatory environments.
  • TF signaling via PAR-2 contributes to cytokine production and macrophage recruitment.

Conclusions:

  • Altered TF expression in endometriosis contributes to the disease's inflammatory nature.
  • TF signaling via PAR-2 exacerbates inflammation and macrophage recruitment in endometriosis.
  • TF represents a promising therapeutic target for managing endometriosis.