Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
Blood Pressure Imbalances and Circulatory Shock01:24

Blood Pressure Imbalances and Circulatory Shock

Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Antihypertensive Drugs: Vasodilators01:23

Antihypertensive Drugs: Vasodilators

Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing the Burden of Operatively Managed Extremity Fractures in Malawi: A Tale of Two Tertiary Hospitals.

World journal of surgery·2026
Same author

Musculoskeletal injury research in sub-Saharan Africa : a ten-year bibliometric analysis of research outputs from Malawi, South Africa, and Tanzania.

Bone & joint open·2026
Same author

Expanding Access to Orthopedic Trauma Care: Evaluation of a Task-Sharing Model With a Remote Quality Assessment Tool for Open Tibia Shaft Fractures in Malawi.

World journal of surgery·2026
Same author

A pilot study on the acceptability and safety of collaborative triage and treatment with traditional bonesetters for extremity fracture patients: a stepped-wedge, cluster-randomised controlled trial in rural Tanzania.

BMJ global health·2025
Same author

Improving intersectoral collaboration between formal healthcare workers and traditional bonesetters in resource-limited settings: evaluation of a pilot collaborative orthopaedic trauma course in rural Tanzania.

BMC medical education·2025
Same author

Advancing Open-Access Education for the Surgical Team Worldwide: The Development and Rollout of the United Nations Global Surgery Learning Hub (SURGhub).

World journal of surgery·2025

Related Experiment Video

Updated: Jul 5, 2026

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
06:10

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

Vasopressor use in septic shock: an update.

Marc Leone1, Claude Martin

  • 1Département d'Anesthésie et de Réanimation et Centre de Traumatologie, Hôpital Nord, Assistance Publique-Hôpitaux de Marseille, Marseille, Cedex 20, France. marc.leone@ap-hm.fr

Current Opinion in Anaesthesiology
|April 30, 2008
PubMed
Summary
This summary is machine-generated.

Norepinephrine and epinephrine are effective vasopressors for septic shock. While low-dose vasopressin may aid refractory cases, its early combination with norepinephrine needs further study. Dopamine is linked to poorer outcomes.

More Related Videos

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients
08:45

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

Related Experiment Videos

Last Updated: Jul 5, 2026

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
06:10

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients
08:45

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

Area of Science:

  • Critical Care Medicine
  • Pharmacology
  • Emergency Medicine

Background:

  • Septic shock management relies heavily on vasopressor agents to restore and maintain hemodynamic stability.
  • Recent advancements have focused on comparing the efficacy and safety of various vasopressors in improving patient survival.

Purpose of the Study:

  • To review recent findings on the comparative effectiveness of different vasopressor agents in the treatment of septic shock.
  • To evaluate the impact of specific vasopressors on patient survival and outcomes.

Main Methods:

  • Review of several large randomized clinical trials and observational studies comparing vasopressor agents.
  • Analysis of data on norepinephrine, epinephrine, dobutamine, dopamine, vasopressin, and nitric oxide inhibitors in septic shock patients.

Main Results:

  • Norepinephrine and epinephrine showed similar survival rates; norepinephrine combined with dobutamine did not significantly differ from epinephrine alone.
  • Observational studies indicated dopamine use was associated with poorer outcomes; a trial comparing dopamine and norepinephrine is pending.
  • Low-dose vasopressin added to norepinephrine did not significantly improve overall survival, but showed a positive effect in a subgroup with moderate shock. Nitric oxide inhibitors were linked to increased mortality.

Conclusions:

  • Norepinephrine or epinephrine can be chosen at the physician's discretion for septic shock treatment.
  • Low-dose vasopressin is a viable option for catecholamine-refractory septic shock.
  • The potential benefits of early vasopressin use in combination with moderate-dose norepinephrine require further investigation.