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Updated: Jul 5, 2026

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension

Published on: May 17, 2024

Age-dependent decrease in 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) activity in hypertensive patients.

Jana Henschkowski¹, Andreas E Stuck, Brigitte M Frey

¹Department of Geriatrics, Inselspital University Hospital, Berne, Switzerland.

American Journal of Hypertension

|April 30, 2008

Summary

This summary is machine-generated.

Reduced 11beta-HSD2 activity is linked to age-related arterial hypertension. This impairment compromises cortisol inactivation, potentially driving hypertension in older adults and offering new treatment targets.

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Last Updated: Jul 5, 2026

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension

Published on: May 17, 2024

Area of Science:

Endocrinology
Gerontology
Cardiovascular Medicine

Background:

Arterial hypertension prevalence increases with age, often without a clear cause.
Age-related hypertension mechanisms are poorly understood but may involve mineralocorticoid receptor overactivation.
A hypothesis suggests age-dependent impairment of 11beta-HSD2 activity leads to cortisol-mediated hypertension.

Purpose of the Study:

To investigate the hypothesis that 11beta-HSD2 activity is age-dependently impaired.
To determine if impaired 11beta-HSD2 activity contributes to age-related arterial hypertension.

Main Methods:

Analyzed urinary steroid hormone metabolites (cortisol, cortisone, and their metabolites) in 165 hypertensive patients using gas chromatography-mass spectrometry.
Assessed apparent 11beta-HSD2 and 11beta-hydroxylase activity and cortisol metabolite excretion.
Correlated metabolite levels and enzyme activities with patient age.

Main Results:

Age positively correlated with ratios suggesting reduced 11beta-HSD2 activity (THF+5alphaTHF)/THE and F/E.
Reduced 11beta-HSD2 activity was observed even after excluding patients with impaired renal function.
Cortisol metabolite excretion was age-independent, likely due to diminished 11beta-hydroxylase activity.

Conclusions:

Reduced 11beta-HSD2 activity is a novel risk factor for hypertension in the elderly.
This finding provides new avenues for developing targeted treatments for age-related hypertension.