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Updated: Jul 5, 2026

Generation of Transgenic Rats using a Lentiviral Vector Approach
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Progress and prospects in rat genetics: a community view.

Timothy J Aitman1, John K Critser, Edwin Cuppen

  • 1Medical Research Council Clinical Sciences Centre and Imperial College London, Du Cane Road, London W12 0NN, UK. t.aitman@csc.mrc.ac.uk

Nature Genetics
|April 30, 2008
PubMed
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Rat genome sequencing accelerates disease gene discovery. Genetic studies in rats are crucial for understanding human disease mechanisms and developing new therapies.

Area of Science:

  • Genetics
  • Genomics
  • Translational Medicine

Background:

  • The rat is a key model organism for studying human diseases.
  • Rat genome sequencing has revolutionized the identification of disease-related genes and pathways.
  • Human genome-wide association studies identify genetic associations but struggle with pinpointing specific genes and mechanisms.

Purpose of the Study:

  • To review achievements in rat gene discovery and its translation to human disease.
  • To highlight the increasing pace of discovering new disease genes, pathways, and mechanisms using rat models.
  • To advocate for continued genetic studies in rats and enhanced genomic infrastructure.

Main Methods:

  • Review of existing literature on rat gene discovery.
  • Analysis of translated findings from rat models to human diseases.

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Last Updated: Jul 5, 2026

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  • Assessment of progress in rat genomic resources and discovery rates.

    • Main Results:

    • Significant progress in rat genomic resources over the past decade.
    • An increasing number of disease genes, pathways, and mechanisms identified through rat research.
    • Successful translation of rat-based findings to understanding human diseases.

    Conclusions:

    • Genetic studies in the rat model are essential for advancing human disease research.
    • Continued development of genomic infrastructure for rat research is vital.
    • Strengthening genetic studies in rats will accelerate the discovery of disease-causing genes and mechanisms.