Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Organization of Genes02:07

Organization of Genes

Overview
Organization of Genes02:07

Organization of Genes

Overview
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Phylogenetic Trees03:21

Phylogenetic Trees

Phylogenetic trees come in many forms. It matters in which sequence the organisms are arranged from the bottom to the top of the tree, but the branches can rotate at their nodes without altering the information. The lines connecting individual nodes can be straight, angled, or even curved.The length of the branches can depict time or the relative amount of change among organisms. For instance, the branch length might indicate the number of amino acid changes in the sequence that underlies the...
Retrieval01:12

Retrieval

Retrieval is the process of getting information out of memory storage and back into conscious awareness. This ability is essential for daily tasks like brushing hair and teeth, driving to work, and performing job duties. Retrieval occurs in three ways: recall, recognition, and relearning.
Recall involves accessing information without cues, such as during an essay test, where individuals must retrieve facts and concepts from memory unaided. Another example is remembering the name of a colleague...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative Genomics of Seasonal Senescence in Forest Trees.

International journal of molecular sciences·2022
Same author

Comparative analysis of alignment-free genome clustering and whole genome alignment-based phylogenomic relationship of coronaviruses.

PloS one·2022
Same author

Siberian larch (Larix sibirica Ledeb.) mitochondrial genome assembled using both short and long nucleotide sequence reads is currently the largest known mitogenome.

BMC genomics·2020
Same author

Amazing symmetrical clustering in chloroplast genomes.

BMC bioinformatics·2020
Same author

Comparison of Real Frequencies of Strings vs. the Expected Ones Reveals the Information Capacity of Macromoleculae.

Journal of biological physics·2013
Same author

The method to compare nucleotide sequences based on the minimum entropy principle.

Bulletin of mathematical biology·2003

Related Experiment Video

Updated: Jul 5, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

Genes, information and sense: complexity and knowledge retrieval.

Michael G Sadovsky1, Julia A Putintseva, Alexander S Shchepanovsky

  • 1Institute of Computational Modelling of RAS, Akademgorodok, 660036, Krasnoyarsk, Russia. msad@icm.krasn.ru

Theory in Biosciences = Theorie in Den Biowissenschaften
|April 30, 2008
PubMed
Summary

Information capacity quantifies nucleotide sequence unexpectedness, revealing genomic order and function. Analyzing sequence patterns helps identify biologically significant "words" linked to structure and function.

More Related Videos

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
07:35

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

Related Experiment Videos

Last Updated: Jul 5, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
07:35

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Information capacity quantifies nucleotide sequence unpredictability.
  • This measure relates to various biological phenomena and sequence analysis.
  • It is defined by maximizing the entropy of nucleotide sequence continuations.

Purpose of the Study:

  • To define and explore the concept of information capacity in nucleotide sequences.
  • To investigate the relationship between information capacity, string length, and genomic order.
  • To identify sequence "words" with high information value and their biological significance.

Main Methods:

  • Defining information capacity as mutual entropy between real and expected sequence frequencies.
  • Analyzing the dependence of information capacity on string length across various genomes.
  • Identifying sequence strings (words) with significant deviations in expected versus real frequencies.

Main Results:

  • Genomic sequences display a multi-minima pattern in information capacity versus string length.
  • This pattern reflects inherent order within the nucleotide sequences.
  • Strings with high information value (significant frequency deviations) are identified.

Conclusions:

  • Information capacity is a valuable metric for understanding genomic sequence order.
  • High information value words are non-randomly distributed, correlating structure with function.
  • This approach aids in deciphering the functional elements encoded within nucleotide sequences.