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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
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Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

Autoimmunity in common variable immunodeficiency.

Susana Lopes-da-Silva1, Luiz Vicente Rizzo

  • 1Serviço de Imunoalergologia, Hospital de Santa Maria, Unidade de Imunologia Clínica, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisbon, Portugal. slopessilva@hsm.min-saude.pt

Journal of Clinical Immunology
|April 30, 2008
PubMed
Summary
This summary is machine-generated.

Autoimmunity is a significant concern in common variable immunodeficiency (CVID). Understanding its causes and improving patient follow-up with early immunoglobulin treatment are key.

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Area of Science:

  • Immunology
  • Clinical Medicine

Background:

  • Autoimmunity is a growing concern in common variable immunodeficiency (CVID), the most frequent symptomatic primary immunodeficiency in adults.
  • High prevalences of autoimmune diseases in CVID patients suggest complex underlying mechanisms.
  • Potential factors include genetic predisposition, immune deficiencies, dysregulation, and impaired tolerance mechanisms.

Purpose of the Study:

  • To review the clinical and immunological profiles of CVID patients with autoimmune diseases.
  • To discuss current and emerging treatment strategies for autoimmunity in CVID.
  • To explore potential improvements in patient follow-up and early detection.

Main Methods:

  • Literature review focusing on autoimmune diseases in CVID.
  • Analysis of clinical and immunological data.
  • Discussion of treatment outcomes and future directions.

Main Results:

  • Autoimmune cytopenias are the most common autoimmune manifestations in CVID.
  • Conventional treatments are standard, with limited data on newer agents like rituximab and infliximab.
  • Early immunoglobulin replacement therapy may offer benefits.

Conclusions:

  • Further research is needed on the clinical/immunological profiles and treatment of autoimmunity in CVID.
  • Early detection and intervention, including immunoglobulin therapy, are crucial for patient management.
  • Identifying predictive markers for autoimmunity could enhance CVID patient care.