Related Experiment Video
Updated: Jul 5, 2026
08:21
A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
Association between local atherosclerosis and renal cell carcinomas
Martina Hager1, Gregor Mikuz, Christian Kolbitsch
1Department of Pathology, Paracelsus Medical University, Salzburg, Austria. hager.martina@gmx.at
Nutrition and Cancer
|April 30, 2008
Summary
Atherosclerosis, characterized by intima-to-media ratio (IMR) >1, is more pronounced in renal cell cancer patients. This suggests atherosclerosis may increase renal cancer risk through oxidative stress.
Area of Science:
- Cardiovascular Pathology
- Oncology
- Renal Medicine
Background:
- Atherosclerosis is linked to oxidative stress and DNA damage.
- Hypoxia in atherosclerosis may elevate cancer risk.
Purpose of the Study:
- To compare atherosclerotic changes morphometrically in renal cell cancer patients versus controls.
- To investigate the association between atherosclerosis and renal cell carcinoma.
Main Methods:
- Morphometric analysis of atherosclerotic changes, including intima-to-media ratio (IMR).
- Comparison of renal cell cancer specimens (n=514) with tumor-negative renal specimens (n=70).
Main Results:
- Renal cell cancer specimens exhibited more advanced atherosclerotic lesions.
- Lesions were more developed in arteries near tumors (near-field) than distant ones (far-field).
- An intima-to-media ratio (IMR) >1 significantly correlated with renal cell carcinoma, increasing cancer odds.
Conclusions:
- Local atherosclerosis is more severe in tumor-positive renal specimens.
- A significant association exists between intima-to-media ratio (IMR) >1 and renal cancer.
- Atherosclerosis-induced oxidative stress is a potential risk factor for renal cell cancer development.
Related Concept Videos
01:27Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
01:30Atherosclerosis I: Introduction
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
01:30Coronary Artery Disease I: Introduction
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...