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Updated: Jul 5, 2026
Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas
Published on: July 21, 2023
Biocompatible ZnO/Au nanocomposites for ultrasensitive DNA detection using resonance Raman scattering
Yichun Liu1, Mingya Zhong, Guiye Shan
1Centre for Advanced Optoelectronic Functional Materials Research, Institute of Genetics and Cytology, Northeast Normal University, Changchun, People's Republic of China. ycliu@nenu.edu.cn
Abstract:
A novel method for identifying DNA microarrays based on ZnO/Au nanocomposites functionalized with thiol-oligonucleotide as probes is descried here. DNA labeled with ZnO/Au nanocomposites has a strong Raman signal even without silver acting as a surface-enhanced Raman scattering promoter. X-ray photoelectron spectra confirmed the formation of a three-component sandwich assay, i.e., constituted DNA and ZnO/Au nanocomposites. The resonance multiple-phonon Raman signal of the ZnO/Au nanocomposites as a spectroscopic fingerprint is used to detect a target sequence of oligonucleotide. This method exhibits extraordinary sensitivity and the detection limit is at least 1 fM.
