Related Experiment Video
Updated: Jul 5, 2026

Standardized Induction and Assessment of Long-term Potentiation-like Cortical Plasticity Using Transcranial Magnetic Stimulation
Published on: November 7, 2025
A local signature of LTP- and LTD-like plasticity in human NREM sleep
Til Ole Bergmann1, Matthias Mölle, Lisa Marshall
1Department of Neurology, Christian-Albrechts University Kiel, Schittenhelmstrasse 10, D-24105 Kiel, Germany. t.bergmann@neurologie.uni-kiel.de
Abstract:
Paired associative stimulation (PAS) repeatedly pairs electrical nerve stimulation with transcranial magnetic stimulation of the contralateral motor hand area (M1(HAND)). Depending on the interstimulus interval, PAS can induce a long-term potentiation (LTP)-like facilitation or long-term depression (LTD)-like suppression of cortical excitability. In three experimental sessions, 12 awake men received PAS of the right median nerve and left M1(HAND) in the evening before sleep. To optimize the timing of paired stimulation in M1(HAND), the interstimulus interval of PAS was adjusted to the individual N20-latency of the somatosensory evoked potential to induce LTP-like effects (PAS(N20+2ms)), LTD-like effects (PAS(N20-5ms)), or no timing-dependent after-effects (PAS(control)). Motor-evoked potentials (MEPs) showed high interindividual variations in the conditioning effects of PAS(N20+2ms) and PAS(N20-5ms) on cortical excitability. However, PAS(control) allowed us to adjust for any unspecific stimulation effects and the MEP increase after PAS(N20+2ms) differed significantly from the MEP decrease after PAS(N20-5ms). PAS(N20+2ms) and PAS(N20-5ms) also had a differential effect on regional expression of slow waves and slow spindle activity during the first hour of subsequent non-rapid eye movement (NREM) sleep. At the electrode sites overlying the conditioned M1(HAND) and the adjacent premotor cortex, local expression of slow spindle activity was significantly correlated with interindividual differences in the efficacy of PAS(N20+2ms) and PAS(N20-5ms) to potentiate or suppress cortical excitability. This correlation indicates that PAS shapes the local regulation of slow sleep spindles during subsequent NREM sleep.
More Related Videos
14:27Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
Published on: August 11, 2019
05:01Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
Published on: September 20, 2024
Related Concept Videos
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
Long-term Depression
Long-term Potentiation
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Potentiation
REM Sleep Behavior Disorder
RBD is significantly associated with...
Stages of Sleep
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...