Related Experiment Video
Updated: Jul 5, 2026
12:27
Modified Laparoscopic Anatomic Hepatectomy: Two-Surgeon Technique Combined with the Simple Extracorporeal Pringle Maneuver
Published on: June 16, 2023
Optimized haemostasis in nephron-sparing surgery using small-intestine submucosa
Jörg Simon1, Robert de Petriconi, Michael Meilinger
1Department of Urology, University of Ulm, Prittwitzstr, 43, 89075 Ulm, Germany. joerg.simon@uniklinik-ulm.de
BMC Urology
|May 1, 2008
Summary
Small-intestine submucosa (SIS) effectively prevents bleeding and urinary fistula after nephron-sparing surgery. This study shows SIS is a safe and easy method to reduce complications in renal tumor removal.
Area of Science:
- Urology
- Surgical Oncology
- Biomaterials in Surgery
Background:
- Nephron-sparing surgery indications are expanding.
- Improved hemostatic techniques aid tumor excision.
- Postoperative bleeding remains a complication.
Purpose of the Study:
- To evaluate the efficacy of small-intestine submucosa (SIS) in preventing postoperative bleeding and urinary fistula.
- To assess SIS as a hemostatic agent in nephron-sparing surgery.
Main Methods:
- Prospective study of 55 nephron-sparing surgeries using SIS in 53 patients.
- SIS applied over the renal defect after tumor resection and hemostatic agent application.
- SIS used for securing the defect and applying compression.
Main Results:
- No open operative revisions were needed for postoperative bleeding.
- No persistent blood loss from drains required substitution.
- No urinomas occurred.
- Pathology included clear-cell/papillary carcinoma, adenoma, oncocytoma, angiomyolipoma.
Conclusions:
- Small-intestine submucosa (SIS) is highly effective.
- SIS is an easy-to-use instrument for preventing complications.
- SIS reduces postoperative bleeding and urinary fistula in nephron-sparing surgery.
