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Human Circadian Phenotyping and Diurnal Performance Testing in the Real World
10:16

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

Published on: April 7, 2020

Delayed sleep phase cases and controls.

Daniel F Kripke1, Katharine M Rex, Sonia Ancoli-Israel

  • 1Department of Psychiatry, University of California, San Diego, La Jolla, California 92093-0667, USA. Kripke.Daniel@ScrippsHealth.org.

Journal of Circadian Rhythms
|May 1, 2008
PubMed
Summary
This summary is machine-generated.

Delayed sleep phase disorder (DSPD) is a familial condition linked to depression. Individuals with DSPD experience significant sleep difficulties and later bedtimes compared to controls.

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Area of Science:

  • Sleep Medicine
  • Genetics
  • Psychiatry

Background:

  • Delayed sleep phase disorder (DSPD) affects sleep timing, with significant heritability suggested.
  • DSPD is characterized by difficulty initiating sleep and late wake times.

Purpose of the Study:

  • To investigate the familial nature of DSPD.
  • To explore associations between DSPD and other traits like depression and mania.

Main Methods:

  • Case series of 205 DSPD participants and 221 controls.
  • DNA samples, extensive questionnaires, and actigraphy were used.
  • Comparison of sleep habits, family history, and psychological traits.

Main Results:

  • DSPD cases had significantly later sleep times than controls.
  • DSPD was associated with more sleep difficulties, poorer sleep quality, and depression.
  • A familial pattern of late bedtimes was reported in DSPD cases.

Conclusions:

  • The DSPD phenotype is familial.
  • DSPD is associated with unipolar depression.