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Published on: November 24, 2021
The tape-stripping technique as a method for drug quantification in skin
J J Escobar-Chávez1, V Merino-Sanjuán, M López-Cervantes
1Departamento de Farmacia y Tecnología Farmacéutica, Universidad de Valencia, Av. Vicente Andrés Estellés s/n, Burjassot, Valencia, España. josefur@yahoo.com
Summary
Tape stripping quantifies drug penetration through the skin, a key method for topical and transdermal delivery research. This technique analyzes drug kinetics and depth within the stratum corneum.
Area of Science:
- Pharmacology
- Dermatology
- Drug Delivery Systems
Background:
- Quantifying drug levels in skin is crucial for topical and transdermal research.
- Traditional methods are vital for understanding drug behavior in the skin.
Purpose of the Study:
- To demonstrate the applications of tape stripping for quantifying drug penetration.
- To highlight the versatility of tape stripping in topical and transdermal drug research.
Main Methods:
- Utilizing horizontal sectioning via tape stripping across the stratum corneum.
- Applying tape stripping to human stratum corneum for drug analysis.
Main Results:
- Tape stripping effectively quantifies drug penetration through the skin.
- The technique allows for the study of drug kinetics and penetration depth.
Conclusions:
- Tape stripping is a versatile and traditional technique for drug quantification in skin.
- This method is essential for advancing topical and transdermal drug delivery research.
