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Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Published on: September 29, 2011

Chronological aging-induced apoptosis in yeast.

Paola Fabrizio¹, Valter D Longo

¹Andrus Gerontology Center, Division of Biogerontology, University of Southern California, Los Angeles, CA 90089-0191, USA. fabrizio@usc.edu

Biochimica Et Biophysica Acta

|May 1, 2008

Summary

Yeast aging studies reveal conserved pathways and programmed death. A specific aging/death program promotes regrowth of adapted mutants in aging Saccharomyces cerevisiae populations.

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Published on: September 29, 2011

Quantifying Yeast Chronological Life Span by Outgrowth of Aged Cells

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A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

Area of Science:

Gerontology
Molecular Biology
Genetics

Background:

Saccharomyces cerevisiae serves as a simple eukaryotic model for aging research.
Chronological lifespan measures survival in non-dividing yeast populations, identifying key aging genes and pathways.
Schizosaccharomyces pombe exhibits chronological aging similar to S. cerevisiae, involving conserved protein homologues.

Purpose of the Study:

To review fundamental genetics of chronological aging in yeast.
To explore the overlap between yeast aging and apoptotic processes.
To highlight an aging/death program facilitating regrowth of adapted mutants in S. cerevisiae.

Main Methods:

Analysis of chronological lifespan paradigms in yeast.
Review of genetic studies identifying life-regulatory genes and aging pathways.
Description of genome-wide screening techniques for studying programmed death.

Main Results:

Identification of conserved pro-aging pathways in yeast.
Evidence of apoptotic death features during yeast chronological aging.
Discovery of an aging/death program promoting dedifferentiation and regrowth of adapted mutants.

Conclusions:

Yeast aging shares fundamental genetic and molecular mechanisms with other eukaryotes.
Programmed death pathways in aging yeast populations can lead to the emergence of fitter variants.
Genome-wide screening is a powerful tool for elucidating mechanisms of programmed death in aging yeast.