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Published on: November 10, 2017

Effect of antihypertensive therapy on serum lipids in newly diagnosed essential hypertensive men

Hanumanthappa Nandeesha1, Purushothaman Pavithran, T Madanmohan

  • 1Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India.

Angiology
|May 1, 2008
PubMed

Insights

Different antihypertensive drugs impact serum lipids differently in men with essential hypertension. Some, like enalapril, improve lipid profiles, while others, such as atenolol and hydrochlorothiazide, may adversely affect triglycerides and cholesterol levels.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Clinical Lipidology

Background:

  • Essential hypertension is a prevalent cardiovascular risk factor.
  • Antihypertensive medications are crucial for managing blood pressure.
  • The impact of various antihypertensives on serum lipid profiles requires detailed investigation.

Purpose of the Study:

  • To evaluate the effects of amlodipine, atenolol, enalapril, hydrochlorothiazide, and a combination of amlodipine and atenolol on serum lipid parameters.
  • To compare the lipid-altering effects of different antihypertensive drug classes in newly diagnosed male essential hypertensive patients.

Main Methods:

  • A randomized study involving 99 newly diagnosed male essential hypertensive patients.
  • Participants received one of five treatment regimens for 8 weeks.
  • Serum lipid profiles, including triglycerides (TGs), very-low-density lipoprotein cholesterol (VLDL-C), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), were measured pre- and post-treatment.

Main Results:

  • Atenolol and hydrochlorothiazide groups showed significant increases in TGs and VLDL-C.
  • Amlodipine and the amlodipine-atenolol combination groups demonstrated significant increases in HDL-C and the HDL-C to LDL-C ratio, with a decrease in the TC to HDL-C ratio.
  • Enalapril treatment resulted in significant reductions in total cholesterol (TC), TGs, VLDL-C, non-HDL-C, and the TG to HDL-C ratio.

Conclusions:

  • Antihypertensive drugs exert varied effects on serum lipid profiles in male patients with essential hypertension.
  • Enalapril exhibits favorable effects on lipid status, whereas atenolol and hydrochlorothiazide may have adverse impacts.
  • Drug selection should consider potential lipid profile alterations in hypertensive patients.

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