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Updated: Jul 5, 2026
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Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome
Published on: July 28, 2023
Evidence vs experience in neonatal practices in necrotizing enterocolitis.
1Department of Surgery, Keck School of Medicine, Childrens Hospital Los Angeles, University of Southern California, Los Angeles, CA 90027, USA.
Summary
Probiotic bacteria show potential in preventing necrotizing enterocolitis (NEC) in premature infants. These beneficial bacteria may strengthen the gut barrier and prevent harmful pathogens, reducing NEC
Area of Science:
- Neonatal medicine
- Gastroenterology
- Microbiology
Background:
- Necrotizing enterocolitis (NEC) is a significant cause of illness and death in premature infants (born <36 weeks gestation).
- The pathogenesis of NEC involves intestinal epithelial damage and bacterial invasion.
- NEC poses a growing global health challenge for vulnerable newborns.
Purpose of the Study:
- To explore the potential of probiotic bacteria in preventing or mitigating NEC.
- To understand the mechanisms by which probiotics may protect against NEC.
Main Methods:
- Investigating the role of bacteria in initiating NEC inflammation.
- Evaluating the effects of probiotic bacteria on the intestinal barrier and pathogen exclusion.
Main Results:
- Probiotic bacteria may enhance the maturation of the intestinal epithelial barrier.
- Probiotics can potentially exclude bacterial pathogens, disrupting NEC pathogenesis.
Conclusions:
- Probiotic therapy represents a promising strategy for NEC prevention in premature infants.
- Further research into probiotic mechanisms is crucial for combating NEC in a growing premature population.
