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Updated: Jul 5, 2026

Fabrication and Characterization of Griffithsin-modified Fiber Scaffolds for Prevention of Sexually Transmitted Infections
Published on: October 31, 2017
Development of controlled release sildenafil formulations for vaginal administration
I Tuncer Değim1, Fatmanur Tuğcu-Demiröz, Sibel Tamer-Ilbasmis
1Faculty of Pharmacy, Department of Pharmaceutical Technology, Gazi University, Ankara, Turkey. tunc@tr.net
Abstract:
Sildenafil is an active substance that has already been approved by FDA for human use. It is known to be an active compound for the treatment of sexual dysfunction in men. Some encouraging results have been published concerning the treatment of infertility with sildenafil in women, but there is no pharmaceutical preparation available. Therefore, various formulations were prepared and the most suitable sildenafil release was found to be with the sildenafil-containing suppositories prepared using Eudragit RS100 and Witepsol H15. The vaginal insert with EVAC 210 polymer containing sildenafil has also provided sildenafil release for a longer period.
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