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Updated: Jul 5, 2026

Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels
Published on: May 18, 2009
Assembly and trafficking of P2X purinergic receptors (Review)
Ruth D Murrell-Lagnado1, Omar S Qureshi
1Department of Pharmacology, University of Cambridge, UK. rdm1003@cam.ac.uk
Abstract:
P2X receptors are cation selective ion channels gated by the binding of extracellular ATP. Seven subtypes have been identified and they have widespread and overlapping distributions throughout the body. They form homo- and heterotrimeric complexes that differ in their functional properties and subcellular localization. They form part of larger signalling complexes, interacting with unrelated ion channels and other membrane and cytosolic proteins. Up- or down-regulation of their expression is associated with several disease states. This review aims to summarize recent work on the assembly and trafficking of this family of receptors.
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