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Updated: Jul 5, 2026

Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells
Published on: September 16, 2020
The morpho-functional organization of secretory traffic. Here today, where tomorrow?
Alberto Luini1, Alexander A Mironov, Maria Antonietta De Matteis
1Department Cell Biology and Oncology, Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro, Chieti, Italy. luini@dcbo.negrisud.it
Abstract:
The morpho-functional principles of secretory traffic are still unclear, in stark contrast with our advanced knowledge of the underlying molecular machineries. Recently, the conceptual and technological hindrances that have delayed progress in this area have been disappearing, and new glimpses of the organization of traffic in intact cells are being revealed by a cluster of powerful morphological techniques. Here, we discuss the new advances in the light of the three main possible traffic principles: by anterograde vesicles, progression/maturation, and flow via continuities.
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