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Optimizing Tubulin Yield from Porcine Brain Tissue
Published on: October 11, 2024
Stereoselective synthesis of 3,3-diarylacrylonitriles as tubulin polymerization inhibitors
Zhenglai Fang1, Yunlong Song, Taradas Sarkar
1Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, and Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA.
Abstract:
A series of 3,3-diarylacrylonitriles were synthesized stereoselectively as tubulin polymerization inhibitors for potential use in cancer chemotherapy. This synthetic route features stannylcupration and palladium-catalyzed Stille cross-coupling chemistry, allowing both E and Z isomers of 3,3-diarylacrylonitriles to be prepared in a very short sequence of reactions.
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