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Gemifloxacin for community-acquired pneumonia
Hartmut M Lode1, Malina Schmidt-Ionas, Ralf Stahlmann
1RCMS, Hohenzollerndamm 2, Ecke Bundesallee, D-10717 Berlin-Wilmersdorf, Germany. haloheck@zedat.fu-berlin.de
Background:
Newer fluoroquinolones have become an important therapeutic choice in the treatment of community-acquired pneumonia (CAP). Gemifloxacin is one of the newest members of this class of antibiotics and has performed favourably in this indication.
Objective:
To analyse the microbiological activity, pharmacokinetic/pharmacodynamic properties and clinical activity of gemifloxacin in CAP, as well as the safety reported in controlled clinical studies.
Methods:
Literature research of English publications in the last 10 years addressing all aspects of gemifloxacin in CAP.
Results/Conclusions:
Gemifloxacin is microbiologically the most active fluoroquinolone against Streptococcus pneumoniae--the leading pathogen of CAP. In several comparative studies gemifloxacin was highly effective and well tolerated in the treatment of mild-to-moderate severe CAP.
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