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Updated: Jul 5, 2026

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
12:24

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

Relation between myocardial edema and myocardial mass during the acute and convalescent phase of myocarditis--a CMR

Anja Zagrosek1, Ralf Wassmuth, Hassan Abdel-Aty

  • 1Franz-Volhard-Klinik, Charité-Campus Buch, Humboldt-University Berlin, Helios-Klinikum, Germany. zagrosek@gmx.de

Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance
|May 2, 2008
PubMed

Insights

Myocardial edema, visualized by T2-weighted CMR, resolves as left ventricular mass decreases during myocarditis healing. This suggests edema is linked to transient mass changes in myocarditis.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Inflammatory Diseases

Background:

  • Myocardial edema is a key indicator of inflammation in myocarditis.
  • The relationship between edema resolution and myocardial mass changes during healing is not well understood.
  • This study investigates the link between myocardial edema and left ventricular mass in myocarditis.

Purpose of the Study:

  • To determine if the resolution of myocardial edema, assessed by T2-weighted CMR, correlates with changes in left ventricular mass.
  • To explore the dynamic changes in myocardial mass during the healing process of myocarditis.

Main Methods:

  • 21 acute myocarditis patients and 11 healthy controls underwent CMR scans.
  • T2-weighted imaging visualized myocardial edema (myocardium/skeletal muscle signal intensity ratio).
  • Left ventricular (LV) mass, volumes, and function were quantified using cine SSFP imaging.

Main Results:

  • LV mass significantly decreased from the acute phase to 1 year follow-up in myocarditis patients (156.7g to 140.3g).
  • Reduced LV mass paralleled the normalization of myocardial signal intensity on T2-weighted images.
  • Interstudy variability in LV mass was higher in patients than controls.

Conclusions:

  • Reversible T2-weighted CMR abnormalities correlate with transient increases in LV mass during myocarditis.
  • Myocardial edema appears to be a common pathway explaining these observed changes.
  • These findings highlight the role of edema in the dynamic changes of myocardial mass during myocarditis.
Abstract

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