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Determinants of quality of life in Marfan syndrome
Paolo Fusar-Poli1, Catherine Klersy, Francesca Stramesi
1DSSAeP, Sezione di Psichiatria, Università di Pavia, Pavia, Italy. p.fusar@libero.it
Background:
Marfan syndrome (MFS) is a rare, heritable disorder that affects connective tissue. Men and women are equally affected. Clinical manifestations involve multiple sites, especially bones and ligaments and heart and blood vessels.
Objective:
Authors sought to investigate quality of life (QoL) in MFS patients, assessing positive and negative sociodemographic factors and self-perceived well-being and functional status.
Method:
Thirty-six patients affected by MFS were interviewed and were administered the SF-36 psychometric questionnaire.
Results:
Subjects affected by MFS reported an impaired quality of life in the psychological domain but not in the physical domain, as compared with a healthy population. Being male and older was significantly associated with a poorer perceived mental QoL.
Conclusion:
The authors found that MFS negatively influences QoL, increases psychological distress, and may be a possible risk for some psychiatric disorders.
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