Related Experiment Video

Updated: Jul 5, 2026

Alternate Immersion in Glucose to Produce Prolonged Hyperglycemia in Zebrafish
05:49

Alternate Immersion in Glucose to Produce Prolonged Hyperglycemia in Zebrafish

Published on: May 5, 2021

Receptor for advanced glycation end product expression in experimental diabetic retinopathy

Yumei Wang1, Franziska Vom Hagen, Frederick Pfister

  • 15th Medical Clinic, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Annals of the New York Academy of Sciences
|May 2, 2008
PubMed

Insights

The advanced glycation end product (AGE)-receptor for AGE (RAGE) pathway is implicated in diabetic retinopathy. Upregulated RAGE in retinal glia, particularly Müller cells, suggests a key role in the disease

Area of Science:

  • Ophthalmology
  • Diabetology
  • Cell Biology

Background:

  • The advanced glycation end product (AGE)-receptor for AGE (RAGE) pathway is implicated in diabetic microvascular complications.
  • RAGE expression and distribution are critical in the pathogenesis of diabetic retinopathy.

Purpose of the Study:

  • To investigate RAGE expression in the retina, with a specific focus on Müller glia, in a rat model of diabetes.
  • To elucidate the role of RAGE in diabetic retinopathy development.

Main Methods:

  • Immunofluorescence and confocal laser microscopy were employed.
  • RAGE expression was analyzed in retinal tissues of non-diabetic and diabetic Sprague Dawley rats.

Main Results:

  • RAGE expression was low in non-diabetic retinae, localized to ganglion cells and Müller cell end feet.
  • In diabetic retinae, RAGE expression was significantly upregulated and predominantly found in retinal glia.
  • Müller cells showed increased RAGE expression in diabetic conditions.

Conclusions:

  • RAGE is upregulated in retinal glia, especially Müller cells, during diabetic retinopathy.
  • Müller cells play a crucial role in regulating vascular permeability, homeostasis, and stress responses in early diabetic retinal damage.
  • RAGE appears to be a central modulator in the pathogenesis of diabetic retinopathy.

More Related Videos

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice04:36

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice

Published on: January 12, 2024

Retinal Pathophysiological Evaluation in a Rat Model09:11

Retinal Pathophysiological Evaluation in a Rat Model

Published on: May 6, 2022

Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...