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Updated: Jul 5, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Diagnostic tests in neonatal sepsis.

Shmuel Arnon¹, Ita Litmanovitz

¹Neonatal Department, Meir Medical Center, Kfar Saba, Israel. harnon@netvision.net.il

Current Opinion in Infectious Diseases

|May 2, 2008

Summary

Early detection of neonatal sepsis relies on diagnostic laboratory markers. Current markers show promise but face challenges in clinical application due to study limitations and accessibility issues.

Area of Science:

Neonatal Medicine
Infectious Diseases
Clinical Diagnostics

Background:

Neonatal sepsis is a critical condition requiring timely diagnosis.
Early detection is crucial for effective treatment and improved outcomes in newborns.

Purpose of the Study:

To review advancements in early neonatal sepsis detection.
To evaluate the clinical utility of diagnostic laboratory markers for neonatal sepsis.

Main Methods:

Review of studies on diagnostic markers for neonatal sepsis.
Analysis of acute phase proteins, cytokines, cell surface antigens, and bacterial genomes.
Assessment of marker performance in retrospective cohorts and single-center studies.

Main Results:

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A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

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Published on: August 12, 2020

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn

A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn

Published on: April 7, 2023

Various markers (proteins, cytokines, antigens, genomes) are used for neonatal sepsis diagnosis.
Studies often have small sample sizes, inconsistent definitions, and varying marker thresholds.
Many markers are not routinely available, require specialized procedures, and are costly.

Conclusions:

Improved understanding of neonatal inflammatory response is needed.
Development of sensitive, specific, and rapid diagnostic tests is essential.
Accurate markers can aid early detection and judicious antibiotic use in neonates.