IgA1 glycosylation in IgA nephropathy: as sweet as it can be
1Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands. j.w.eijgenraam@lumc.nl
Kidney International
|May 2, 2008
Abstract:
Abnormally O-glycosylated IgA1 is likely to be involved in the pathogenesis of IgA nephropathy (IgAN). Buck et al. show that the enzyme activity and gene expression of specific glycosyltransferases, in purified B cells isolated from peripheral blood and bone marrow, is not reduced in IgAN patients. As only a small fraction of IgA in IgAN patients is abnormally glycosylated, it is probable that a more detailed molecular analysis at the single cell level is required to unravel the cause of this abnormality.
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