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Updated: Jul 5, 2026

A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli
Published on: August 12, 2016
The proposed terminology 'A(1c)-derived average glucose' is inherently imprecise and should not be adopted
Z T Bloomgarden1, S E Inzucchi, E Karnieli
1Mount Sinai School of Medicine, New York, NY 10028, USA. zbloomgard@aol.com
Abstract:
The proposed use of a more precise standard for glycated (A(1c)) and non-glycated haemoglobin would lead to an A(1c) value, when expressed as a percentage, that is lower than that currently in use. One approach advocated to address the potential confusion that would ensue is to replace 'HbA(1c)' with a new term, 'A(1c)-derived average glucose.' We review evidence from several sources suggesting that A(1c) is, in fact, inherently imprecise as a measure of average glucose, so that the proposed terminology should not be adopted.
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