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Related Concept Videos

Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
G-Protein Gated Ion Channels01:21

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GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory organs,...
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Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
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Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
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Related Experiment Video

Updated: Jul 5, 2026

P50 Sensory Gating in Infants
12:55

P50 Sensory Gating in Infants

Published on: December 26, 2013

Sensory gating: a translational effort from basic to clinical science.

Howard C Cromwell1, Ryan P Mears, Li Wan

  • 1Department of Psychology, Bowling Green State University, Ohio 43403, USA. hcc@bgsu.edu

Clinical EEG and Neuroscience
|May 3, 2008
PubMed
Summary

Sensory gating (SG), a key brain process for filtering information, is impaired in psychiatric disorders. Recent research in animals and humans reveals its neural basis, brain distribution, and influences, highlighting the need for integrated studies.

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Psychiatry

Background:

  • Sensory gating (SG) is crucial for information processing and filtering.
  • Impaired SG is linked to various psychiatric disorders.
  • Recent advancements in animal and human research offer new insights into SG.

Purpose of the Study:

  • To review recent findings on sensory gating from both animal and human studies.
  • To provide an overview of different methodologies used to investigate SG.
  • To highlight the implications of these findings for understanding brain function and disorders.

Main Methods:

  • Review of recent animal research on single neuron and scalp recording studies of SG.
  • Analysis of human research using deep electrode recordings.
  • Examination of the influence of organismal state and pharmacology on SG.

Main Results:

  • Animal studies show SG in single neurons and diverse brain regions, influenced by state and nicotine.
  • Human studies identify SG in cortical regions near the hippocampus, with later hippocampal involvement than expected.
  • Multiple SG subtypes exist, varying in circuit dependence and state influence.

Conclusions:

  • Sensory gating is a complex process found across various brain structures and influenced by multiple factors.
  • Integrative approaches combining animal and human research are essential for a comprehensive understanding of SG.
  • Further research is needed to elucidate the precise mechanisms and clinical relevance of SG subtypes.