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Vascular insufficiency quantitatively aggravates diabetic neuropathy.

Z Ram1, M Sadeh, R Walden

  • 1Department of Neurosurgery, Chaim Sheba Medical Center, Tel-Hashomer, Israel.

Archives of Neurology
|December 1, 1991
PubMed
Summary

Lower limb ischemia significantly worsens diabetic neuropathy, particularly affecting nerve function. This suggests oxygen deprivation (hypoxia) plays a key role in diabetic nerve damage.

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Area of Science:

  • Neurology
  • Vascular Medicine
  • Diabetology

Background:

  • Diabetic neuropathy is a common complication.
  • Peripheral vascular disease can affect lower limbs in diabetics.
  • The relationship between ischemia and neuropathy severity needs further clarification.

Purpose of the Study:

  • To investigate the impact of lower-limb ischemia on diabetic neuropathy severity.
  • To correlate vascular disease severity with neurological findings in diabetic patients.

Main Methods:

  • Assessed 48 diabetic patients with peripheral vascular disease.
  • Scored vascular disease severity using medical history, physical findings, and lab data.
  • Rated neuropathy clinically and via nerve conduction studies (common peroneal, posterior tibial, sural nerves).

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Main Results:

  • Found significant correlations between vascular scores and neurologic variables (coefficients .6–.7).
  • Electrophysiologic data showed the strongest correlation.
  • Nondiabetic controls had no neuropathy despite ischemia; diabetic controls without ischemia had symmetrical neuropathy.

Conclusions:

  • Lower-limb ischemia exacerbates diabetic neuropathy.
  • Hypoxia is implicated in the pathogenesis of diabetic neuropathy.