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Updated: Jul 5, 2026

In Vitro Colony Assays for Characterizing Tri-potent Progenitor Cells Isolated from the Adult Murine Pancreas
Published on: June 10, 2016
Weighing up beta-cell mass in mice and humans: self-renewal, progenitors or stem cells?
Neil A Hanley1, Karen Piper Hanley, Päivi J Miettinen
1Centre for Human Development, Stem Cells & Regeneration, University of Southampton, Southampton, UK. N.A.Hanley@soton.ac.uk
Abstract:
Understanding how beta-cells maintain themselves in the adult pancreas is important for prioritizing strategies aimed at ameliorating or ideally curing different forms of diabetes. There has been much debate over whether beta-cell proliferation, as a means of self-renewal, predominates over the existence and differentiation of a pancreatic stem cell or progenitor cell population. This article describes the two opposing positions based largely on research in laboratory rodents and its extrapolation to humans.
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