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Alexander's Law revisited
Benjamin Jeffcoat1, Alexander Shelukhin, Alex Fong
1Department of Otolaryngology and Communicative Sciences, Anatomy and Neurology, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
Journal of Neurophysiology
|May 3, 2008
Summary
Alexander
Area of Science:
- Neuroscience
- Vestibular System
Background:
- Alexander's Law describes gaze-evoked nystagmus changes in unilateral vestibular lesions.
- This effect has been observed with cold caloric stimulation, suggesting peripheral vestibular inhibition.
Purpose of the Study:
- To investigate the gaze effect on nystagmus from unilateral warm caloric irrigation.
- To differentiate between two proposed hypotheses for Alexander's Law.
Main Methods:
- Unilateral warm water ear irrigation was used to induce nystagmus.
- The slow-phase velocity of nystagmus was measured at different gaze directions.
Main Results:
- A gaze effect, similar to that seen with cold irrigation, was observed with warm irrigation.
- Results support the hypothesis of gaze-dependent modulation of the vestibulo-ocular reflex (VOR).
Conclusions:
- The gaze effect in nystagmus is consistent across different caloric stimulation types.
- The findings support a VOR modulation mechanism over a leaky neural integrator model for Alexander's Law.
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