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Updated: Jul 5, 2026

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients
Published on: April 18, 2025
Hypoxemia in inferior pulmonary veins in supine position is dependent on obesity
Teiichi Yamane1, Taro Date, Michifumi Tokuda
1Division of Cardiology, Department of Internal Medicine, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan. yamanet1@aol.com
Rationale:
Although arterial oxygen concentration decreases in obese subjects, the mechanism for this remains to be determined.
Objectives:
The blood gas level in each pulmonary vein (PV) was measured in supine subjects with diverse body mass index (BMI) values, to determine whether there was a regional insufficiency in gas exchange depending on the subject's BMI.
Methods:
Forty subjects with normal cardiopulmonary function who underwent a catheter ablation for atrial fibrillation were included. Before delivering any radiofrequency energy application, blood samples were obtained from each of the four PVs during physiologic breathing in a supine position to measure the PO2 and PCO2 values. Spirometry and ventilation/perfusion lung scintigraphy were also performed.
Measurements And Main Results:
The PO2 value was significantly higher in superior veins than inferior veins (91.8 +/- 13.5, 70.8 +/- 16.3, 92.2 +/- 11.1, and 73.6 +/- 13.7 mm Hg, in the left superior, left inferior, right superior, and right inferior PV, respectively). There was a significant inverse relationship between the PO2 and PCO2 values. Neither the spirometry nor lung scintigraphy could detect any remarkable findings corresponding to the low PO2 values. Among the various clinical characteristics, only the BMI was significantly associated with the decreased PO2 value in the inferior veins.
Conclusions:
Hypoxia in obese subjects in a supine position is thus considered to be primarily caused by insufficient gas exchange in the regions of lung linked to the inferior PVs. The inverse relationship between the BMI and PO2 value in the inferior PVs suggests a possible subclinical manifestation of obesity-related respiratory insufficiency.
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