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Updated: Jul 5, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
2-[N-(X-chlorophenyl)carbamoyl]benzenesulfonamide (with X = 2 and 4)
Waseeq Ahmad Siddiqui1, Saeed Ahmad, Islam Ullah Khan
1Department of Chemistry, University of Sargodha, Sargodha, Pakistan.
Abstract:
The structures of 2-[N-(2-chlorophenyl)carbamoyl]benzenesulfonamide and 2-[N-(4-chlorophenyl)carbamoyl]benzenesulfonamide, both C(13)H(11)ClN(2)O(3)S, are stabilized by extensive intra- and intermolecular hydrogen bonds. In both structures, sulfonamide groups are hydrogen bonded via the N and O atoms and form chains of molecules. The carbamoyl groups are also hydrogen bonded, involving the O and N atoms, further strengthening the polymeric chains running along the c and a axes in the 2- and 4-chloro derivatives, respectively. Carbamoylsulfonamide derivatives are novel compounds with a great potential for medicinal applications.
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