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Desvenlafaxine succinate monohydrate.

Nalivela Venu¹, Bukkapattanam R Sreekanth, Thaimattam Ram

¹Centre for Excellence in Polymorphism and Particle Engineering, Dr Reddy's Laboratories Ltd, IPDO Innovation Plaza, Bachupally, Hyderabad, India.

Acta Crystallographica. Section C, Crystal Structure Communications

|May 3, 2008

Summary

This summary is machine-generated.

This study details the crystal structure of a new antidepressant, O-desmethylvenlafaxine (desvenlafaxine) succinate salt. Its unique hydrogen-bonding network explains its high thermal stability and solubility.

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Published on: June 28, 2011

Area of Science:

Crystallography
Materials Science
Pharmacology

Background:

O-desmethylvenlafaxine (desvenlafaxine) is a novel antidepressant drug.
The compound is formulated as a succinate salt, with four known polymorphs.
Understanding the crystal structure is crucial for drug development.

Purpose of the Study:

To characterize a specific polymorph of the desvenlafaxine succinate salt.
To elucidate the role of hydrogen bonding in the compound's structural properties.
To correlate crystal structure with thermal stability and solubility.

Main Methods:

Single-crystal X-ray diffraction analysis.
Analysis of hydrogen-bonding interactions and network formation.
Thermal analysis (desolvation and melting point determination).

Main Results:

The crystal structure reveals a rare anti conformation of the succinate anion.
Distinct hydrogen-bonded networks are formed by cations (desvenlafaxine) and anions (succinate) with water molecules.
A strong, interconnected hydrogen-bonding network leads to simultaneous desolvation and melting at approximately 402 K.

Conclusions:

The crystal structure provides molecular-level insights into the thermal stability and solubility of desvenlafaxine succinate.
The identified hydrogen-bonding patterns are key to the compound's physical properties.
This structural understanding aids in the development and formulation of this new antidepressant.