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Enhancing Prostate Tumor Biobanking Reliability with Improved Sampling Technique and Histological Characterization
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Functional evidence implicating S100P in prostate cancer progression.

Gargi D Basu1, David O Azorsa1, Jeffrey A Kiefer1

  • 1Pharmaceutical Genomics Division, The Translational Genomics Research Institute, Scottsdale, AZ.

International Journal of Cancer
|May 3, 2008
PubMed
Summary

Elevated S100P protein levels promote prostate cancer growth and metastasis by upregulating androgen receptor expression. This suggests S100P is an oncogene and a potential therapeutic target for aggressive prostate cancer.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • S100P protein is implicated in calcium signaling and cellular processes.
  • Elevated S100P levels in prostate cancer correlate with metastatic disease progression.

Purpose of the Study:

  • To investigate the functional role of S100P in prostate cancer growth, progression, and therapeutic resistance.
  • To elucidate the molecular mechanisms by which S100P influences prostate cancer.

Main Methods:

  • Modulating S100P expression (overexpression and siRNA-mediated silencing) in prostate cancer cell lines (PC3 and 22Rv1).
  • Assessing cell proliferation, apoptosis, anchorage-independent growth, and tumor formation in vivo.
  • Utilizing microarray analysis to identify involved signaling pathways.

Main Results:

  • S100P overexpression in PC3 cells enhanced cell growth, S-phase progression, and anchorage-independent growth, while decreasing apoptosis.
  • S100P-overexpressing cells showed increased resistance to camptothecin-induced apoptosis.
  • Silencing S100P in 22Rv1 cells induced a cytostatic effect.
  • In vivo studies showed significantly increased tumor formation in S100P-overexpressing cells.
  • Microarray analysis revealed increased androgen receptor expression in S100P-overexpressing cells.

Conclusions:

  • S100P overexpression promotes prostate cancer progression by upregulating androgen receptor expression and enhancing cell growth.
  • S100P exhibits oncogenic properties in prostate cancer and may confer resistance to chemotherapy.
  • S100P is a potential therapeutic and chemosensitization target, and a biomarker for aggressive prostate cancer.