DigesTip: a new device for a rapid and efficient in-solution protein digestion
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Updated: Jul 5, 2026

Evaluation of Protein–Protein Interactions using an On-Membrane Digestion Technique
Published on: July 19, 2019
Roberto Marangoni1, Riccardo Chiarini, Giorgio Iannone
1ProteoGen Bio S.r.l., Pontedera, Pisa, Italy. marangon@di.unipi.it
Abstract:
DigesTip is a new device for in-solution protein digestion, based on a patent pending technology, able to immobilize enzymes (trypsin, in this case) on a solid surface, keeping their activity preserved. DigesTip is a standard pipette tip, usable both by human and by robots. Its main performances are: very short digestion time (1 min) and usability with low protein sample concentrations (5 microg/mL). DigesTip obtains a clear signal in MS measurements and its usage rules out several preparative steps.
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