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Related Experiment Video

Updated: Jul 5, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Lupus nephritis in children.

Farkhanda Hafeez¹, Abid Mahmood Tarar, Rashid Saleem

¹Department of Nephrology, The Children's Hospital and Institute of Child Health, Lahore,Pakistan. drfarkh@hotmail.com

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

|May 3, 2008

Summary

Lupus nephritis in children commonly presents with diffuse proliferative glomerulonephritis. Early immunosuppressive therapy effectively controls this condition in most pediatric nephrology patients.

Area of Science:

Pediatric Nephrology
Immunology
Rheumatology

Background:

Lupus nephritis is a severe renal complication of Systemic Lupus Erythematosus (SLE).
Understanding the clinicopathological patterns in pediatric patients is crucial for effective management.

Purpose of the Study:

To determine the clinicopathological pattern of lupus nephritis in pediatric nephrology patients.
To analyze the histological lesions, clinical manifestations, and treatment outcomes.

Main Methods:

A case series study was conducted in a pediatric nephrology department over five years.
Twenty-six pediatric patients (up to 16 years) with primary SLE and renal involvement were included.
Percutaneous renal biopsies were performed, and histological lesions were classified using WHO criteria.

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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Main Results:

Diffuse proliferative glomerulonephritis was the most common histological lesion (n=14), followed by membranous nephropathy (n=6).
Edema (80.76%) and hypertension (46.15%) were the most frequent clinical manifestations.
Proteinuria was universal (100%), while azotemia occurred in 19.33% of patients. Disease control was achieved in 73.07% with immunosuppressive therapy.

Conclusions:

Diffuse proliferative glomerulonephritis is the predominant histological finding in pediatric lupus nephritis in this cohort.
Renal involvement typically manifests within two years of SLE onset and is manageable with immunosuppressive therapy.