Related Experiment Video

Updated: Jul 5, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Lupus nephritis in children

Farkhanda Hafeez1, Abid Mahmood Tarar, Rashid Saleem

  • 1Department of Nephrology, The Children's Hospital and Institute of Child Health, Lahore,Pakistan. drfarkh@hotmail.com

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|May 3, 2008
PubMed

Insights

Lupus nephritis in children commonly presents with diffuse proliferative glomerulonephritis. Early immunosuppressive therapy effectively controls this condition in most pediatric nephrology patients.

Area of Science:

  • Pediatric Nephrology
  • Immunology
  • Rheumatology

Background:

  • Lupus nephritis is a severe renal complication of Systemic Lupus Erythematosus (SLE).
  • Understanding the clinicopathological patterns in pediatric patients is crucial for effective management.

Purpose of the Study:

  • To determine the clinicopathological pattern of lupus nephritis in pediatric nephrology patients.
  • To analyze the histological lesions, clinical manifestations, and treatment outcomes.

Main Methods:

  • A case series study was conducted in a pediatric nephrology department over five years.
  • Twenty-six pediatric patients (up to 16 years) with primary SLE and renal involvement were included.
  • Percutaneous renal biopsies were performed, and histological lesions were classified using WHO criteria.

Main Results:

  • Diffuse proliferative glomerulonephritis was the most common histological lesion (n=14), followed by membranous nephropathy (n=6).
  • Edema (80.76%) and hypertension (46.15%) were the most frequent clinical manifestations.
  • Proteinuria was universal (100%), while azotemia occurred in 19.33% of patients. Disease control was achieved in 73.07% with immunosuppressive therapy.

Conclusions:

  • Diffuse proliferative glomerulonephritis is the predominant histological finding in pediatric lupus nephritis in this cohort.
  • Renal involvement typically manifests within two years of SLE onset and is manageable with immunosuppressive therapy.
Abstract

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