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Updated: Jul 5, 2026

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
Published on: March 8, 2015
[Basal ganglia deep-brain stimulation for treatment of drug-resistant epilepsy: review and current data]
S Chabardès1, L Minotti, S Chassagnon
1Clinique universitaire de neurochirurgie, pôle tête, cou et chirurgie réparatrice, hôpital Michallon,CHU de Grenoble, B.P. 217, 38043 Grenoble cedex, France. SChabardes@chu-grenoble.fr
Abstract:
The surgical treatment of intractable epilepsies involving eloquent areas of the cortex is still challenging. Deep-brain stimulation could be an alternative to resective surgery because it can modulate the remote control systems of epilepsy, such as the thalamus and basal ganglia. The surgical experience acquired in the field of movement disorder surgery and the low morbidity of this technic could allow one to apply DBS to intractable epilepsies, such as generalized, motor and bitemporal epilepsies. Here we discuss the main experimental and clinical data reported so far in the literature and taken from our own experience.
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