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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

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Related Experiment Video

Updated: Jul 5, 2026

Profiling Individual Human Embryonic Stem Cells by Quantitative RT-PCR
09:03

Profiling Individual Human Embryonic Stem Cells by Quantitative RT-PCR

Published on: May 29, 2014

StemBase: a resource for the analysis of stem cell gene expression data.

Christopher J Porter1, Gareth A Palidwor, Reatha Sandie

  • 1Ottawa Health Research Institute, Molecular Medicine Program, Ontario, Canada.

Methods in Molecular Biology (Clifton, N.J.)
|May 6, 2008
PubMed
Summary

StemBase is a gene expression database for stem cells. It helps researchers study gene expression patterns and identify potential stem cell markers.

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Area of Science:

  • * Stem cell biology
  • * Bioinformatics
  • * Genomics

Background:

  • * Gene expression analysis is crucial for understanding stem cell biology.
  • * Existing databases may lack comprehensive data on stem cell gene expression profiles.
  • * Identifying specific gene expression patterns can reveal stem cell functions and markers.

Purpose of the Study:

  • * To introduce StemBase, a dedicated database for stem cell gene expression data.
  • * To demonstrate the utility of StemBase for investigating gene expression in stem cells.
  • * To facilitate the discovery of novel stem cell markers and functional genes.

Main Methods:

  • * Data compilation from DNA microarrays and Serial Analysis of Gene Expression (SAGE).
  • * Focus on gene expression data from mouse and human stem cells and their derivatives.
  • * Database design for efficient querying and analysis of gene expression profiles.

Main Results:

  • * StemBase provides a centralized resource for stem cell gene expression data.
  • * The database enables the study of specific gene expression in various stem cell types.
  • * Users can search for genes exhibiting particular expression profiles relevant to stem cell function.

Conclusions:

  • * StemBase serves as a valuable tool for stem cell research.
  • * The database can accelerate the identification of stem cell-specific genes and markers.
  • * StemBase supports a deeper understanding of stem cell biology through expression profiling.