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Updated: Jul 5, 2026

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
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Imaging studies in emphysema.

Paul J Friedman1

  • 1Department of Radiology, University of California San Diego Medical Center, San Diego, CA 92103-8749, USA. pfriedman@ucsd.edu

Proceedings of the American Thoracic Society
|May 6, 2008
PubMed
Summary
This summary is machine-generated.

Computed tomography (CT) offers advanced detection of emphysema, a component of chronic obstructive pulmonary disease. Quantitative CT analysis surpasses traditional methods for accurately measuring emphysema severity and distribution.

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Area of Science:

  • Pulmonary Medicine
  • Radiology
  • Medical Imaging

Background:

  • Chronic obstructive pulmonary disease (COPD) encompasses various emphysema types.
  • Chest radiography traditionally identifies emphysema but lacks sensitivity.
  • Computed tomography (CT) scanning significantly enhances diagnostic capabilities.

Purpose of the Study:

  • To define emphysema subtypes within COPD.
  • To describe classic radiographic findings of emphysema.
  • To highlight the advancements in CT scanning for emphysema assessment.

Main Methods:

  • Review of classic chest radiograph findings.
  • Analysis of computed tomography (CT) scanning techniques, including "density mask" and "percentile point" measurements.
  • Evaluation of factors affecting CT scan comparability (lung inflation, slice thickness, etc.).

Main Results:

  • CT scanning demonstrates improved sensitivity and specificity over radiography.
  • CT visualizes the severity and distribution of low-attenuation areas indicative of emphysema.
  • Quantitative CT analysis is more sensitive than subjective interpretation of CT scans.

Conclusions:

  • Quantitative CT has become the preferred method for measuring emphysema.
  • CT provides a more detailed assessment of emphysema compared to traditional radiography.
  • Standardization of CT parameters is crucial for cross-study comparisons.