Related Experiment Video
Updated: Aug 12, 2026

Intracellular Refolding Assay
Published on: January 24, 2012
Heat shock proteins and systemic lupus erythematosus
V Dhillon1, D Latchman, D Isenberg
1Department of Biochemistry, UCL, London, UK.
Abstract:
This review briefly defines the heat shock proteins (hsps), their classification and their functions. The hypothesis that links hsps to the development of autoimmunity is explored, together with the rationale for investigation of the relationship between hsps and systemic lupus erythematosus (SLE). Thus, published work on this subject falls into three main categories: the overexpression of hsps in SLE, the development of autoantibodies to hsps in SLE, and the surface expression of hsps in peripheral blood mononuclear cells in SLE. This work is reviewed in detail. In conclusion, we describe areas for further study and outline ways in which this is being approached.
Related Concept Videos
Molecular Chaperones and Protein Folding
The...
Regulation of the Unfolded Protein Response
Molecular Chaperones and Protein Folding
The...
Bacterial Protein Maturation
Other Stress Responses in Bacteria
Hypersensitivity Reactions: Immune-Complex Reactions

