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Overproduction, purification, crystallization and preliminary X-ray analysis of human Fe65-PTB2 in complex with the

Jens Radzimanowski1, Konrad Beyreuther, Irmgard Sinning

  • 1Heidelberg University Biochemistry Center, INF328, D-69120 Heidelberg, Germany.

Acta Crystallographica. Section F, Structural Biology and Crystallization Communications
|May 6, 2008
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Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...