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Updated: Jul 5, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
14:28

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

Determinants of endothelial function in human immunodeficiency virus infection: a complex interplay among therapy,

Kristin E Mondy1

  • 1Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA. kmondy@im.wustl.edu

Journal of the Cardiometabolic Syndrome
|May 6, 2008
PubMed

Insights

Highly active antiretroviral therapy (HAART) for human immunodeficiency virus (HIV) can lead to metabolic issues and increased cardiovascular disease (CVD) risk. Understanding these complex mechanisms is key for managing long-term HIV care.

Area of Science:

  • Cardiovascular Science
  • Infectious Disease
  • Metabolic Syndrome

Background:

  • Human immunodeficiency virus (HIV) infection is now a chronic condition due to highly active antiretroviral therapy (HAART).
  • HIV-infected individuals face increased risks of metabolic complications and cardiovascular disease (CVD).
  • Previous studies indicate higher premature CVD risk in HIV patients compared to the general population.

Purpose of the Study:

  • To explore the multifactorial mechanisms regulating endothelial function in HIV-infected individuals.
  • To identify factors contributing to cardiovascular disease risk in the context of HIV and HAART.

Main Methods:

  • Review of epidemiologic and clinical studies on HIV, HAART, and cardiovascular health.
  • Analysis of factors affecting endothelial function in HIV cohorts.

Main Results:

  • HIV infection and HAART are associated with metabolic complications like insulin resistance and dyslipidemia.
  • Endothelial dysfunction is common in HIV-infected populations.
  • Multiple factors, including direct viral effects, lipid changes, inflammation, HAART, and host factors, influence endothelial function.

Conclusions:

  • Endothelial dysfunction in HIV is complex and influenced by viral, treatment, and host-related factors.
  • Improved understanding of these mechanisms is crucial for effective long-term HIV management.
  • Strategies to mitigate CVD risk in HIV patients require further development.

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