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Iatrogenic microemboli of pulmonary arteries in infants
1Department of Cell Pathophysiology, Medical Center for Postgraduate Education, Warszawa.
Abstract:
The identification of emboli of the pulmonary arterioles with foreign bodies by means of morphologic examination was made in 5 infants aged from 8 days to 5 months. Positive results of special staining procedures of foreign bodies, particularly when applying for the first time a dye Siriusrot F3B, used in the textile industry, permitted an identification of the bodies localized both intra- and extravascularly as cotton fibres. The origin of fibres, tissue reactions, and the pathogenetic significance of the emboli due to foreign bodies are discussed.
Insights
Foreign body emboli, identified as cotton fibers using Siriusrot F3B dye, were found in pulmonary arterioles of infants. This study discusses their origin, tissue reactions, and significance.
Area of Science:
- Pediatric Pathology
- Pulmonary Medicine
- Toxicology
Background:
- Pulmonary embolism in infants can have various causes.
- Morphologic examination is crucial for identifying the nature of emboli.
- Specialized staining techniques can aid in foreign body identification.
Observation:
- Five infants, aged 8 days to 5 months, presented with emboli in pulmonary arterioles.
- Morphologic examination revealed the presence of foreign bodies within the emboli.
- Intra- and extravascular foreign bodies were observed.
Findings:
- Special staining procedures, including the novel use of Siriusrot F3B dye, identified the foreign bodies as cotton fibers.
- Cotton fibers were confirmed as the causative agent of the pulmonary emboli in all observed cases.
- The origin and tissue reactions associated with these cotton fiber emboli were analyzed.
Implications:
- This finding highlights a potential iatrogenic or environmental hazard in infants.
- Understanding the pathogenetic significance of foreign body emboli is crucial for diagnosis and prevention.
- The use of Siriusrot F3B dye offers a new method for identifying textile-related foreign bodies in biological tissues.