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Updated: Jul 5, 2026
06:44
Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
Published on: September 8, 2017
Biweekly docetaxel-containing chemotherapy may be the optimal schedule
Xinmiao Yang1, Yang Cai, Xinmin Zhao
1Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China.
Anti-Cancer Drugs
|May 6, 2008
Summary
Biweekly docetaxel and mitoxantrone chemotherapy demonstrated significant efficacy and tolerability in advanced breast cancer patients. This dosing schedule offers a promising treatment option, potentially improving outcomes.
Area of Science:
- Oncology
- Pharmacology
Background:
- Docetaxel dosing impacts clinical activity and toxicity.
- Triweekly docetaxel shows higher antitumor activity but severe hematological toxicity.
- Weekly docetaxel may have less activity or fewer adverse events.
Purpose of the Study:
- To evaluate the efficacy and toxicity of biweekly docetaxel and mitoxantrone in advanced breast cancer.
- To determine the optimal dosing schedule for docetaxel in combination chemotherapy.
Main Methods:
- 59 advanced breast cancer patients received intravenous docetaxel (60 mg/m²) and mitoxantrone (8 mg/m²) every 2 weeks.
- Objective response rates, time to progression, overall survival, and adverse events were assessed.
Main Results:
- Objective response rate was 54.2%.
- Median time to progression was 6.8 months (10.3 months for responders, 3.6 months for non-responders).
- Grade III/IV neutropenia (61.0%) was the most frequent severe adverse event; overall survival was 16.9 months.
Conclusions:
- Biweekly docetaxel and mitoxantrone is effective and well-tolerated for advanced breast cancer.
- The biweekly schedule may represent an optimal dosing strategy for docetaxel in combination chemotherapy.
- This regimen offers a viable treatment option for patients with advanced breast cancer.
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