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1Department of Applied Therapeutics, Faculty of Pharmacy, Health Sciences Center,Kuwait University, P.O. Box 24923, Safat 13110, Kuwait. j.n.sharma@hsc.edu.kw
Thescientificworldjournal
|May 6, 2008
Summary
The kallikrein-kinin system is vital for heart health. Its deficiency contributes to cardiovascular diseases, but enhancing this system shows therapeutic promise for conditions like hypertension.
Area of Science:
- Cardiovascular Physiology
- Kallikrein-Kinin System Biology
Background:
- The kallikrein-kinin system (KKS) is present in cardiac muscle, and its dysfunction is linked to cardiac issues.
- Reduced KKS activity is implicated in cardiovascular diseases such as diabetes, hypertension, and myocardial infarction.
Purpose of the Study:
- To explore the role of the KKS in cardiovascular health and disease.
- To evaluate the therapeutic potential of modulating the KKS for cardiovascular and renal disorders.
Main Methods:
- Review of clinical and experimental data on KKS activity in various cardiovascular conditions.
- Analysis of the mechanisms underlying the cardioprotective effects of angiotensin-converting enzyme inhibitors.
- Assessment of kallikrein gene delivery and kinin agonists as therapeutic strategies.
Main Results:
- Deficiency in the KKS can lead to cardiac dysfunction and contribute to cardiovascular diseases.
- Angiotensin-converting enzyme inhibitors exert cardioprotective effects partly through kinin release, aiding left ventricular hypertrophy regression.
- Kallikrein gene therapy and kinin agonists show potential for treating hypertension and cardiovascular/renal diseases.
Conclusions:
- The kallikrein-kinin system plays a crucial role in maintaining cardiac function.
- Modulating the KKS offers a promising therapeutic avenue for cardiovascular and renal diseases.
- While beneficial, potential adverse effects of KKS-targeting therapies require consideration.
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