Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen

Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen

Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...

Acute Respiratory Failure-V

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...

Pneumonia IV: Management

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:

Endotracheal Intubation I: Procedure

Endotracheal Intubation I: Procedure

Endotracheal or ET intubation is a critical medical procedure used to secure a patient's airway, often in acute respiratory distress, apnea, upper airway obstruction, ineffective clearance of secretions, high risk for aspiration, or during general anesthesia.
The ET tube comprises various components, including a standard adaptor to attach a bag-valve-mask (BVM) or ventilator, a cuff, a pilot balloon, and radiopaque markings along its length to measure the insertion distance. The tube sizes...

Mechanical Ventilation II: Invasive Ventilation

Mechanical Ventilation II: Invasive Ventilation

Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...

Mechanical Ventilation III: Noninvasive Ventilation

Mechanical Ventilation III: Noninvasive Ventilation

Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation (NIPPV)

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Current and future strategies aiming at reducing catecholamine exposure in septic shock.

Critical care (London, England)·2026

Same author

Validation of the inferior vena cava collapsibility as a predictive marker of fluid responsiveness in spontaneously breathing patients.

Scientific reports·2026

Same author

Prospective multicentre study of upper respiratory mucosal transcriptomics reveals two major endotypes of critically ill COVID-19 patients.

Communications medicine·2026

Same author

Clinical Phenotypes of Critically Ill Patients with COVID-19 Infected with Omicron: A Nationwide Prospective Cohort Study.

Infectious diseases and therapy·2026

Same author

Allocation and prognosis of temporary mechanical circulatory support in unselected cardiogenic shock: Insights from the FRENSHOCK registry.

Archives of cardiovascular diseases·2025

Same author

RAGE contributes to persistent sepsis-induced muscle and mitochondrial alterations.

Scientific reports·2025

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

Preoxygenation Techniques for Tracheal Intubation in Critically Ill Adults Utilizing Oxygen Mask and Noninvasive Ventilation

Preoxygenation Techniques for Tracheal Intubation in Critically Ill Adults Utilizing Oxygen Mask and Noninvasive Ventilation

Published on: December 5, 2025

Antimicrobial treatment for ventilator-associated tracheobronchitis: a randomized, controlled, multicenter study.

Saad Nseir¹, Raphaël Favory, Elsa Jozefowicz

¹Réanimation Médicale, boulevard du Pr Leclercq, Hôpital Calmette, CHRU de Lille, 59037 Lille Cedex, France. s-nseir@chru-lille.fr

Critical Care (London, England)

|May 6, 2008

Summary

Antibiotic treatment for ventilator-associated tracheobronchitis (VAT) significantly increases ventilator-free days and reduces subsequent pneumonia and ICU mortality. However, it does not shorten the overall duration of mechanical ventilation.

More Related Videos

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Published on: June 28, 2018

Related Experiment Videos

Last Updated: Jul 5, 2026

Preoxygenation Techniques for Tracheal Intubation in Critically Ill Adults Utilizing Oxygen Mask and Noninvasive Ventilation

Preoxygenation Techniques for Tracheal Intubation in Critically Ill Adults Utilizing Oxygen Mask and Noninvasive Ventilation

Published on: December 5, 2025

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Published on: June 28, 2018

Area of Science:

Critical Care Medicine
Infectious Diseases
Pulmonology

Background:

Ventilator-associated tracheobronchitis (VAT) prolongs mechanical ventilation.
The efficacy of antibiotic treatment for VAT remains a critical clinical question.

Purpose of the Study:

To evaluate the impact of antibiotic treatment on mechanical ventilation duration in patients with VAT.
To assess secondary outcomes including subsequent ventilator-associated pneumonia (VAP) and intensive care unit (ICU) mortality.

Main Methods:

A prospective, randomized, controlled, multicenter study.
Patients with VAT were randomized to receive 8 days of intravenous antibiotics or no antibiotics.
Exclusion criteria included prior VAP or severe immunosuppression.

Main Results:

Antibiotic treatment was associated with significantly more ventilator-free days (12 vs. 2 days).
Subsequent VAP rates were significantly lower in the antibiotic group (13% vs. 47%).
ICU mortality was significantly reduced with antibiotic treatment (18% vs. 47%).

Conclusions:

Antimicrobial therapy for VAT improves ventilator-free days and reduces VAP and ICU mortality.
Total duration of mechanical ventilation was not significantly impacted by antibiotic treatment.