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Serological profile of potential solid organ donors in Santa Catarina, Brazil

Robson P do Amaral1, Rodrigo P do Amaral, A E K T de Saidneuy

  • 1Universidade Federal de Santa Catarina, Florianópolis, Brazil. robinhoamaral@hotmail.com

Transplantation Proceedings
|May 6, 2008
PubMed

Insights

Cytomegalovirus (CMV) and toxoplasmosis infections are highly prevalent in potential blood donors. This study assessed seroprevalence of various infectious diseases in this group.

Area of Science:

  • Infectious Diseases
  • Transfusion Medicine
  • Serology

Background:

  • Serological testing is a critical component of the blood donation process to ensure transfusion safety.
  • Identifying the prevalence of infectious agents among potential donors is essential for public health and blood supply integrity.

Purpose of the Study:

  • To determine the seroprevalence of cytomegalovirus (CMV), toxoplasmosis, human immunodeficiency virus (HIV), HTLV, Chagas disease, hepatitis B virus (HBV), hepatitis C virus (HCV), and syphilis (Lues) in a cohort of potential blood donors.
  • To provide data on the prevalence of these infections within the donor population.

Main Methods:

  • Sera from 233 potential blood donors were tested between January 2006 and April 2007.
  • Standard serological assays were employed to detect antibodies or antigens for the specified infectious agents.

Main Results:

  • Cytomegalovirus (CMV) immunoglobulin G (IgG) seroprevalence was high at 89.3%.
  • Toxoplasmosis IgG antibody also showed high prevalence.
  • Hepatitis B virus (HBV) showed 27% positivity for anti-HBc, with only three individuals testing HBsAg-positive.
  • Human immunodeficiency virus (HIV), hepatitis C virus (HCV), HTLV, and Chagas disease exhibited low seroprevalence.

Conclusions:

  • Cytomegalovirus (CMV) and toxoplasmosis are highly prevalent among the studied potential blood donor population.
  • The findings highlight the importance of continued serological screening in blood donation to manage endemic infections.
Abstract

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