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A case of an intraventricular inflammatory pseudotumor presumably caused by Epstein-Barr virus infection

Hiroshi Nishioka1, Makoto Shibuya, Satoshi Nakajima

  • 1Department of Neurosurgery, Hachioji Medical Center, Tokyo Medical University, Tokyo 193-0998, Japan. nishioka@tokyo-med.ac.jp

Surgical Neurology
|May 6, 2008
PubMed
Abstract

Insights

This case highlights inflammatory pseudotumor (IP), a rare CNS lesion, presenting as a ventricular mass. The patient

Area of Science:

  • Neurology
  • Pathology
  • Oncology

Background:

  • Inflammatory pseudotumor (IP) is a rare lesion primarily affecting the central nervous system (CNS) with an uncertain etiology.
  • Intraventricular mass lesions can present diagnostic challenges.

Observation:

  • A 67-year-old male presented with an involuntary movement disorder in the left upper extremity.
  • MRI revealed a solid, homogeneously-enhanced tumor in the right lateral ventricle near the thalamus.
  • The patient had a history of thalamic hemorrhage and chronic sinusitis with an orbital mass, suspected to be IP.

Findings:

  • Partial tumor removal and subsequent analysis confirmed the diagnosis of inflammatory pseudotumor (IP).
  • The IP was associated with Epstein-Barr virus (EBV) infection.
  • The simultaneous occurrence of multiple IPs suggests an exaggerated immune response post-EBV infection.

Implications:

  • Inflammatory pseudotumor should be considered in the differential diagnosis of intraventricular mass lesions.
  • EBV infection may play a role in the pathogenesis of multiple IPs.
  • This case expands the understanding of IP presentation and potential triggers.

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